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Compartmentalisation of the Developing Trigeminal Ganglion Into Maxillary and Mandibular Divisions Does Not Depend on Target Contact by LISA SCOTT; MARTIN E. ATKINSON is a Earth and Planetary Sciences article available to read on EtoBox.

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During development axons contact their target tissues with phenomenal accuracy but the mechanisms that control this homing behaviour remain largely elusive. A prerequisite to the study of the factors involved in hard‐wiring the nervous system during neurogenesis is an accurate calendar of developmental events. We have studied the maxillary and mandibular components of the trigeminal system to determine the stages during embryogenesis when a gross somatotopic order is first established within the trigeminal ganglion and the axons projecting to the brainstem. The retrograde transganglionic fluorescent tracers DiO and DiI were injected into the maxillary and mandibular arches or their derivatives in fixed mouse embryos staged between 13 and 40 somites (E9–E11). After 1–4 wk, the distribution of the 2 tracers was determined using confocal laser scanning microscopy. The first maxillary nerve cell bodies and their developing axons were labelled at the 30 somite stage (E10). This was 2 somite stages earlier than the mesencephalic nucleus and the ganglion cell bodies of the mandibular nerve. The gross somatotopic division of cells within the trigeminal ganglion projecting to the maxillary

Who reads Compartmentalisation of the Developing Trigeminal Ganglion Into Maxillary and Mandibular Divisions Does Not Depend on Target Contact?

Author

LISA SCOTT; MARTIN E. ATKINSON

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0021-8782)

Published

1999

Language

EN

Field

Earth and Planetary Sciences (Physical Sciences)