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Exercise training and cognition in multiple sclerosis: The GET Smart trial protocol by Charles H. Bombardier; Robert W. Motl; Ralph H.B. Benedict; Nancy Temkin; Peiqing Qian; Katharine Alexander; Annabeth Evans; Andrea Thomas; Kristin Toms; Cathea M. Carey; George H. Kraft is a Medicine article available to read on EtoBox.

What is Exercise training and cognition in multiple sclerosis: The GET Smart trial protocol about?

## Background and objectives: Multiple sclerosis (ms) causes cognitive impairment in approximately 50% of cases. disease modifying medications and cognitive rehabilitation produce only small positive effects on cognition in ms. converging animal and human research suggests that aerobic exercise may improve cognition in people with ms, but definitive trials are lacking. we describe the design of the get smart study, a randomized controlled trial comparing the effects of aerobic exercise versus stretching and toning on cognition in ms. ## Methods: The study is a single-blind, parallel group randomized (1:1) controlled trial that compares aerobic exercise training with an active control group consisting of stretching and toning exercises for improving cognition. participants are nondepressed, ambulatory, non-exercising adults with ms aged 18-54 years who have below average cognitive processing speed. both treatments were designed to generate equivalent outcome expectancies and entailed supervised, progressive exercise programs, 3 times per week for up to 40 min over a 6 month period. ## Projected patient outcomes: The primary hypothesis is that the aerobic training group will demonstr

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Author

Charles H. Bombardier; Robert W. Motl; Ralph H.B. Benedict; Nancy Temkin; Peiqing Qian; Katharine Alexander; Annabeth Evans; Andrea Thomas; Kristin Toms; Cathea M. Carey; George H. Kraft

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)