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Treponema pallidum causes the chronic systemic infection known as syphilis. It is usually sexually transmitted and characterized by periods of active disease separated by latency. The primary stage presents as a painless chancre that heals within 4-6 weeks but lymphadenopathy may persist for months. Secondary syphilis causes generalized mucocutaneous lesions, lymphadenopathy, and constitutional symptoms like fever and weight loss. Tertiary syphilis can lead to destructive lesions of internal organs or the n

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