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MDM2-Binding Chalcone Targets OSCC Apoptosis by Sergio Pinheiro is a document available to read on EtoBox.

This study presents a novel 1,2,3-triazole-chalcone hybrid compound (1f) that exhibits significant cytotoxicity and selectivity against oral squamous cell carcinoma (OSCC), outperforming traditional chemotherapeutics like carboplatin and doxorubicin. The compound induces apoptosis and cell cycle arrest at the G2/M phase, and shows potential affinity for the MDM2 protein, suggesting a promising pharmacological profile. Overall, 1f is proposed as a lead candidate for the development of new chemotherapeutic ag

Author

Sergio Pinheiro

Language

EN