Can I read Role of fibronectin during biological apatite crystal nucleation: Ultrastructural characterization on EtoBox?

Role of fibronectin during biological apatite crystal nucleation: Ultrastructural characterization by G. Daculsi; P. Pilet; M. Cottrel; G. Guicheux is a Medicine article available to read on EtoBox.

What is Role of fibronectin during biological apatite crystal nucleation: Ultrastructural characterization about?

The role of adhesion molecules like osteopontin and bone sialoprotein, both containing the Arg-Gly-Asp sequence have been shown to have a role in mineral formation, whereas fibronectin (FN), another adhesive protein, was never studied during the mineralization processes. The formation and maturation of biological apatite crystals are under matrix control, and one of the roles of specific crystal proteins is to control the nucleation and growth of biological apatite during the mineralization process (promotion or inhibition). In the case of calcium phosphate ceramic used as a bone substitute, a dissolution-precipitation process occurs after implantation before the bone ingrowth and bone mineralization. The early precipitation consists of common biological apatite crystals. These crystals are the result of secondary nucleation and a heteroepitaxic growth process on synthetic residual crystals. In in vivo studies, hydroxyapatite crystals were implanted subcutaneously into mice for 1 or 2 weeks. Fibronectin immunogold labeling of the newly formed crystals on surfaces of high-resolution transmission electron microscopy sections of retrieved implants revealed the close association of the

Who reads Role of fibronectin during biological apatite crystal nucleation: Ultrastructural characterization?

Author

G. Daculsi; P. Pilet; M. Cottrel; G. Guicheux

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1999

Language

EN

Field

Medicine (Health Sciences)