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This study investigates the role of C/EBPβ phosphorylation at a specific ERK/GSK3 site in the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes. The findings reveal that phosphorylation of C/EBPβ is essential for the expression of adiponectin and C/EBPα, with mutations affecting this phosphorylation site altering adipogenic activity. The results underscore the importance of the MEK/ERK signaling pathway in regulating adipogenesis and adiponectin product

Author

woocheukkiu

Language

EN