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Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium by Talal El Zarif; Amin H. Nassar; Elio Adib; Bailey G. Fitzgerald; Jiaming Huang; Tarek H. Mouhieddine; Paul G. Rubinstein; Taylor Nonato; Rana R. McKay; Mingjia Li; Arjun Mittra; Dwight H. Owen; Robert A. Baiocchi; Michael Lorentsen; Christopher Dittus; Nazli Dizman; Adewunmi Falohun; Noha Abdel-Wahab; Adi Diab; Anand Bankapur; Alexandra Reed; Chul Kim; Aakriti Arora; Neil J. Shah; Edward El-Am; Elie Kozaily; Wassim Abdallah; Ahmad Al-Hader; Batool Abu Ghazal; Anwaar Saeed; Claire Drolen; Melissa G. Lechner; Alexandra Drakaki; Javier Baena; Caroline A. Nebhan; Tarek Haykal; Michael A. Morse; Alessio Cortellini; David J. Pinato; Alessia Dalla Pria; Evan Hall; Veli Bakalov; Nathan Bahary; Aarthi Rajkumar; Ankit Mangla; Vishal Shah; Parminder Singh; Frank Aboubakar Nana; Nerea Lopetegui-Lia; Danai Dima; Ryan W. Dobbs; Pauline Funchain; Rabia Saleem; Rachel Woodford; Georgina V. Long; Alexander M. Menzies; Carlo Genova; Giulia Barletta; Sonam Puri; Vaia Florou; Dame Idossa; Maristella Saponara; Paola Queirolo; Giuseppe Lamberti; Alfredo Addeo; Melissa Bersanelli; Dory Freeman; Wanling Xie; Erin G. Reid; Elizabeth Y. Chiao; Elad Sharon; Douglas B. Johnson; Ramya Ramaswami; Mark Bower; Brinda Emu; Thomas U. Marron; Toni K. Choueiri; Lindsey R. Baden; Kathryn Lurain; Guru P. Sonpavde; Abdul Rafeh Naqash is a Medicine article available to read on EtoBox.
What is Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium about?
## PURPOSE Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use of ICIs in PWH and cancer. ## METHODS This retrospective study included PWH treated with anti–PD-1- or anti–PD-L1-based therapies for advanced cancers. Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS). Objective response rates (ORRs) were measured per RECIST 1.1 or other tumor-specific criteria, whenever feasible. Restricted mean survival time (RMST) was used to compare OS and PFS between matched PWH and PWOH with metastatic NSCLC (mNSCLC). ## RESULTS Among 390 PWH, median age was 58 years, 85% (n = 331) were males, 36% (n = 138) were Black; 70% (n = 274) received anti–PD-1/anti–PD-L1 monotherapy. Most common cancers were NSCLC (28%, n = 111), hepatocellular carcinoma ([HCC]; 11%, n = 44), and head and neck squamous cell carcinoma (HNSCC; 10%, n = 39). Seventy percent (152/216) had CD4+ T cell counts ≥200 cells/μL, and 94% (179/190) had HIV viral load <400 copies/mL. Twenty percent (79/390) had a
Who reads Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium?
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- Author
- Talal El Zarif; Amin H. Nassar; Elio Adib; Bailey G. Fitzgerald; Jiaming Huang; Tarek H. Mouhieddine; Paul G. Rubinstein; Taylor Nonato; Rana R. McKay; Mingjia Li; Arjun Mittra; Dwight H. Owen; Robert A. Baiocchi; Michael Lorentsen; Christopher Dittus; Nazli Dizman; Adewunmi Falohun; Noha Abdel-Wahab; Adi Diab; Anand Bankapur; Alexandra Reed; Chul Kim; Aakriti Arora; Neil J. Shah; Edward El-Am; Elie Kozaily; Wassim Abdallah; Ahmad Al-Hader; Batool Abu Ghazal; Anwaar Saeed; Claire Drolen; Melissa G. Lechner; Alexandra Drakaki; Javier Baena; Caroline A. Nebhan; Tarek Haykal; Michael A. Morse; Alessio Cortellini; David J. Pinato; Alessia Dalla Pria; Evan Hall; Veli Bakalov; Nathan Bahary; Aarthi Rajkumar; Ankit Mangla; Vishal Shah; Parminder Singh; Frank Aboubakar Nana; Nerea Lopetegui-Lia; Danai Dima; Ryan W. Dobbs; Pauline Funchain; Rabia Saleem; Rachel Woodford; Georgina V. Long; Alexander M. Menzies; Carlo Genova; Giulia Barletta; Sonam Puri; Vaia Florou; Dame Idossa; Maristella Saponara; Paola Queirolo; Giuseppe Lamberti; Alfredo Addeo; Melissa Bersanelli; Dory Freeman; Wanling Xie; Erin G. Reid; Elizabeth Y. Chiao; Elad Sharon; Douglas B. Johnson; Ramya Ramaswami; Mark Bower; Brinda Emu; Thomas U. Marron; Toni K. Choueiri; Lindsey R. Baden; Kathryn Lurain; Guru P. Sonpavde; Abdul Rafeh Naqash
- Publisher
- American Society of Clinical Oncology (ASCO)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)