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Histological Study of Normal and Tumor-bearing Liver Treated with Focused Ultrasound by Lili Chen; Gail ter Haar; David Robertson; John P.M Bensted; Christopher R Hill is a Medicine article available to read on EtoBox.

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The purpose of this investigation was to study the tissue damage (including blood vessels) on both normal and tumor-bearing experimental livers and the course of liver repair after focused ultrasound (FUS) treatment using histological evaluation. A series of experiments were carried out in vivo. Tissue was treated using arrays of ultrasound exposures with a frequency of 1.7 MHz, in situ spatially averaged focal intensity (I SAL in situ) of 212-266 W/cm 2 (corresponding to in situ spatial peak intensity of 382-479 W/cm 2 ), 5-10 s exposure duration and 1.5-3.0 mm exposure separation. Tissue specimens were examined using both light and electron microscopy. The damage to the blood vessel walls was studied. The results showed the existence of indirect tissue damage in both normal and tumor tissue that is outside of the treatment volume, due to disruption of the major blood vessels supplying the adjacent area. Evidence for liver regeneration was found 2 months after FUS treatment.

Who reads Histological Study of Normal and Tumor-bearing Liver Treated with Focused Ultrasound?

Author

Lili Chen; Gail ter Haar; David Robertson; John P.M Bensted; Christopher R Hill

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0301-5629)

Published

1999

Language

EN

Field

Medicine (Health Sciences)