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Exogenous Endothelin-1 Causes Peripheral Insulin Resistance in Healthy Humans by A. OTTOSSON-SEEBERGER; J.M. LUNDBERG; A. ALVESTRAND; G. AHLBORG is a Medicine article available to read on EtoBox.

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In states of insulin resistance, increased plasma levels of endothelin‐1 and a disturbed vascular reactivity have been reported. In order to investigate the effects of endothelin‐1 on peripheral insulin sensitivity and the vasoactive interactions between insulin and endothelin‐1, six healthy subjects were studied on two different occasions with the euglycaemic hyperinsulinaemic clamp technique combined with an intravenous infusion of either endothelin‐1 (4 pmol kg^−1^ min^−1^) or 0.9% sodium chloride. During the endothelin‐1 infusion, arterial plasma endothelin‐1 levels rose 10‐fold. The endothelin‐1 infusion reduced insulin sensitivity as demonstrated by a 31 ± 7% decrease in whole‐body glucose uptake (__P__< 0.05) and a 26 ± 11% fall in leg glucose uptake (__P__< 0.05) compared with the control protocol. During the state of hyperinsulinaemia, exogenous endothelin‐1 increased mean arterial blood pressure by 8 ± 1% (__P__< 0.05) and decreased splanchnic and renal blood flow by 30 ± 6% (__P__< 0.001) and 20 ± 4% (__P__< 0.001), respectively. However, the endothelin‐1 infusion did not lower skeletal muscle blood flow measured as leg and forearm blood flow. In summary, exogenous endot

Who reads Exogenous Endothelin-1 Causes Peripheral Insulin Resistance in Healthy Humans?

Author

A. OTTOSSON-SEEBERGER; J.M. LUNDBERG; A. ALVESTRAND; G. AHLBORG

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

1997

Language

EN

Field

Medicine (Life Sciences)