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Phenotypic evidence for inducible multiple antimicrobial resistance in Salmonella choleraesuis by Robert J Tibbetts; Tsang Long Lin; Ching Ching Wu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Phenotypic evidence for inducible multiple antimicrobial resistance in Salmonella choleraesuis about?

Multiple antimicrobial resistance (MAR) in Salmonella choleraesuis is becoming a major concern. It has been demonstrated that a MAR phenotype can be induced in Escherichia coli and other members of the Enterobacteriaceae by exposing the isolates to salicylates, various antimicrobials, or organic solvents used to combat and control bacterial infection. Therefore the purpose of the present study was to determine whether this marA-associated MAR-phenotype is inducible in S. choleraesuis. Isolates used in the present study were able to withstand toxic effects of the organic solvent cyclohexane naturally, or following exposure to the inducing compounds salicylate, tetracycline, or chloramphenicol. All isolates possessed fragments of marA with the predicted size of 408 bp when amplified using marA-specific primers by PCR. The resulting PCR products that were sequenced revealed that amplified S. choleraesuis marA was 99% and 85% homologous to the published Salmonella typhimurium and E. coli marA sequences respectively. Minimum inhibitory concentrations of tetracycline (P<0.08), chloramphenicol (P<0.001), rifampin (P<0.08), and nalidixic acid (P<0.001) against cyclohexane-tolerant mutants

Who reads Phenotypic evidence for inducible multiple antimicrobial resistance in Salmonella choleraesuis?

Author

Robert J Tibbetts; Tsang Long Lin; Ching Ching Wu

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0378-1097)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)