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Film Drying and Complexation Effects in the Simultaneous Skin Permeation of Ketoprofen and Propylene Glycol from Simple Gel Formulations by Jenna L. Bowen; Charles M. Heard is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Film Drying and Complexation Effects in the Simultaneous Skin Permeation of Ketoprofen and Propylene Glycol from Simple Gel Formulations about?

This work investigated the simultaneous permeation of ketoprofen and propylene glycol (PG) across pig ear skin from simple gel formulations administered under simulated in-use conditions. The aims were to quantify rates of permeation of both solvent and active, probe the effects of formulation drying and gain insight into drag/complexation interactions. Simple 3-component gels were formulated using a fixed amount of ketoprofen and hydroxypropyl cellulose thickener with decreasing content of solvent propylene glycol. Multiple finite (5 mg x 15 mg) doses were massaged over 24h into full thickness pig ear skin in vertical Franz-type diffusion cells. The permeation of ketoprofen was inversely proportional to the content of PG, whereas the permeation of PG was directly proportional, although the amount of PG permeated was always greater than ketoprofen, even from the driest gel practically achievable. In this state, the molar ratio of PG/ketoprofen was approximately 12, suggesting that this number of PG molecules constitutes the solvation cage of ketoprofen. Dragging/pulling effect extends throughout the skin and into the receptor compartment and probably the system, in an in vivo situa

Who reads Film Drying and Complexation Effects in the Simultaneous Skin Permeation of Ketoprofen and Propylene Glycol from Simple Gel Formulations?

Author

Jenna L. Bowen; Charles M. Heard

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2006

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)