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Electronic home monitoring of children with cystic fibrosis to detect and treat acute pulmonary exacerbations and its effect on 1-year FEV1 by Muruvvet Yanaz; Cansu Yilmaz Yegit; Aynur Gulieva; Mine Kalyoncu; Merve Selcuk; Burcu Uzunoglu; Gamze Tastan; Almala Pinar Ergenekon; Yasemin Gokdemir; Ela Erdem Eralp; Fazilet Karakoc; Bulent Karadag is a Medicine article available to read on EtoBox.
What is Electronic home monitoring of children with cystic fibrosis to detect and treat acute pulmonary exacerbations and its effect on 1-year FEV1 about?
Background: We aimed to investigate the effect of the use of electronic home spirometry in children with cystic fibrosis (CF) on 1-year FEV 1 (% predicted, pp) change. Methods: This is a randomised, one-year prospective study including children with CF between 6 and 18 years of age. Subjects were randomised into home spirometry group (HSG) and usual care group (UCG). Children in HSG performed two pulmonary function tests (PFT) per week. Data regarding acute pulmonary exacerbations (PEx) was obtained from patients' records. At baseline and 12th month, health related quality of life questionnaire for CF patients (CFQ-R) and lung clearance index (LCI) were performed. Results: Sixty children were recruited with a median (IQR) age of 13.3 (11.4-15.4) years. Absolute change in FEV 1 pp from baseline to 12th month as median (IQR) was +1% (-6.75-9.75) in HSG and -2.50% (-7.50-3.25) in UCG (p = 0.10). Sensitivity analysis including only adherent children in HSG (n = 22), yielded an increase of 5% (-3.50-12) in HSG and a decrease of 2.50% (-7.50-3.25) in UCG (p = 0.009). A total of 29 (96.7%) subjects in HSG and 23 (76.7%) in UCG had PEx (p = 0.05). Absolute change in median (IQR) LCI 2.5 fr
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- Author
- Muruvvet Yanaz; Cansu Yilmaz Yegit; Aynur Gulieva; Mine Kalyoncu; Merve Selcuk; Burcu Uzunoglu; Gamze Tastan; Almala Pinar Ergenekon; Yasemin Gokdemir; Ela Erdem Eralp; Fazilet Karakoc; Bulent Karadag
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)