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B-type natriuretic peptides as powerful markers in cardiac diseases – analytical and clinical aspects by Angelika Hammerer-Lercher; Bernd Puschendorf; Johannes Mair is a Medicine article available to read on EtoBox.

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## Abstract Among all natriuretic peptides and neurohormones, B-type natriuretic peptide (BNP) and its N-terminal prohormone fragment (NT-proBNP) have been shown to be the best and most powerful markers to identify patients with acute and chronic heart failure (HF). The fully automated BNP and NT-proBNP assays require only 15–20 min to achieve a test result so that a turn-around time of less than 60 min is possible, as requested by the guidelines of the cardiological societies. The in-vitro stabilities of BNP and NT-proBNP are sufficient for routine use. Most of the commercially available assays, except if they are sublicensed, use different antibodies. This may explain that in general, BNP and NT-proBNP assays show close correlations, but do not agree in absolute values. The assays have not been standardized so far and the application of various calibration materials may contribute to different results. Thus, reference ranges are dependent on the assay used, and reference ranges have to be determined for each assay separately. The increasing values with age may be related to the increasing frequency of subclinical renal or cardiac dysfunction in the elderly. Estrogens stimulate th

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Author

Angelika Hammerer-Lercher; Bernd Puschendorf; Johannes Mair

Publisher

Walter de Gruyter GmbH

Published

2006

Language

EN

Field

Medicine (Health Sciences)