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Evaluating the Longer-term Cognitive Effects of Adjunctive Perampanel Compared to Lacosamide in a Naturalistic Outpatient Setting by Carolin Meschede; Juri-Alexander Witt; Michael Rademacher; Randi D. von Wrede; Christian E. Elger; Christoph Helmstaedter is a Medicine article available to read on EtoBox.
What is Evaluating the Longer-term Cognitive Effects of Adjunctive Perampanel Compared to Lacosamide in a Naturalistic Outpatient Setting about?
## Purpose: This retrospective longitudinal study aims to compare the longer-term cognitive and behavioral side effects of adjunctive antiepileptic treatment with perampanel (per) and lacosamide (lcm), two third generation antiepileptic drugs with suggested favorable cognitive profiles. the two drugs were monitored according to a previously established routine diagnostic protocol (helmstaedter et al. e&b 2013;26:182-7) which facilitates the retrospective comparison of antiepileptic drug tolerability in a naturalistic outpatient setting. ## Methods: Records from 94 patients were evaluated who underwent neuropsychological assessment before and under adjunctive treatment with either per (n = 57) or lcm (n = 37). cognition was assessed using the epitrack screening for executive functions and a vlmt short form for verbal memory. subjective assessments included a german qolie-10 adaptation (quality of life) and an extended adverse events profile (aep). the median follow-up interval was 36 weeks. ## Results: Multivariate repeated measures statistics revealed a non-significant trend towards an interaction effect "time - treatment arm" on both executive function and memory. when analyzed se
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- Author
- Carolin Meschede; Juri-Alexander Witt; Michael Rademacher; Randi D. von Wrede; Christian E. Elger; Christoph Helmstaedter
- Publisher
- Elsevier BV
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)