Opening book details…
Can I read Anti-Proliferative Effects of Evodiamine on Human Thyroid Cancer Cell Line ARO on EtoBox?
Anti-Proliferative Effects of Evodiamine on Human Thyroid Cancer Cell Line ARO by Meng-Ching Chen; Ching-Han Yu; Shyi-Wu Wang; Hsiao-Fung Pu; Shu-Fen Kan; Lie-Chwen Lin; Chin-Wen Chi; Lary Low-Tone Ho; Chen-Hsen Lee; Paulus S. Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Anti-Proliferative Effects of Evodiamine on Human Thyroid Cancer Cell Line ARO about?
## Abstract The incidence of thyroid cancer increases with age, and it is twice in women as common as in men. The undifferentiated thyroid cancer (UTC) is the most aggressive of all thyroid cancers. Unfortunately, there are almost no efficacious therapeutic modalities. It is important to develop some new effective therapies. Evodiamine is a chemical extracted from a kind of Chinese herb named Wu‐Chu‐Yu and has been demonstrated to be effective in preventing the growth of a variety of cancer cells. In the present study, the mechanism by which evodiamine inhibited the undifferentiated thyroid cancer cell line ARO was examined. Based on 3‐(4,5‐dimethylthiazol ‐2‐yle)2,5‐diphenyltetrazolium bromide (MTT) assay, cell proliferation rate was reduced dose‐dependently by evodiamine, but not by rutaecarpine. According to the flow cytometric analysis, evodiamine treatment resulted in G2/M arrest and DNA fragmentation in ARO cells. The G2/M arrest was accompanied with an increase of the expression of cdc25C, cyclin B1, and cdc2‐p161 protein, and it was also with a decrease of the expression of cdc2‐p15. Furthermore, by using the TUNEL assay, evodiamine‐induced apoptosis was observed at 48 h an
Who reads Anti-Proliferative Effects of Evodiamine on Human Thyroid Cancer Cell Line ARO?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Meng-Ching Chen; Ching-Han Yu; Shyi-Wu Wang; Hsiao-Fung Pu; Shu-Fen Kan; Lie-Chwen Lin; Chin-Wen Chi; Lary Low-Tone Ho; Chen-Hsen Lee; Paulus S. Wang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)