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Virus-induced Neuronal Apoptosis as Pathological and Protective Responses of the Host by Isamu Mori; Yukihiro Nishiyama; Takashi Yokochi; Yoshinobu Kimura is a Medicine article available to read on EtoBox.

What is Virus-induced Neuronal Apoptosis as Pathological and Protective Responses of the Host about?

## Abstract Extensive efforts have been made to elucidate mechanisms by which viruses induce apoptosis in cultured neuronal cells. However, little is yet understood about the mechanisms of neuronal apoptosis __in vivo__ as well as interpretations of this active host response. Here we review recent advances toward understanding these topics. The c‐Jun __N__‐terminal protein kinase cascade may be an important apoptotic mediator in virally infected neurons, which comes in focus as a therapeutic target for protecting neurons from death. A novel concept can be proposed that virus‐induced neuronal apoptosis in the central nervous system may represent a pathological host response, while that in the peripheral counterpart, especially olfactory receptor neurons, may mediate a protective host response. Copyright © 2004 John Wiley & Sons, Ltd.

Who reads Virus-induced Neuronal Apoptosis as Pathological and Protective Responses of the Host?

Author

Isamu Mori; Yukihiro Nishiyama; Takashi Yokochi; Yoshinobu Kimura

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1052-9276)

Published

2004

Language

EN

Field

Medicine (Health Sciences)