Opening book details…
Can I read Peripheral Inflammatory Biomarkers Predict the Deposition and Progression of Amyloid-β in Cognitively Unimpaired Older Adults on EtoBox?
Peripheral Inflammatory Biomarkers Predict the Deposition and Progression of Amyloid-β in Cognitively Unimpaired Older Adults by Lauren E. Oberlin; Kirk I. Erickson; Rachel Mackey; William E. Klunk; Howard Aizenstein; Brian J. Lopresti; Lewis H. Kuller; Oscar L. Lopez; Beth E. Snitz is a Neuroscience article available to read on EtoBox.
What is Peripheral Inflammatory Biomarkers Predict the Deposition and Progression of Amyloid-β in Cognitively Unimpaired Older Adults about?
## Introduction: Systemic inflammation has been increasingly implicated in the pathogenesis of alzheimer's disease (ad), yet the mechanistic and temporal specificity of this relationship is poorly understood. we aimed to characterize the cross-sectional and longitudinal associations between peripheral inflammatory biomarkers, cognition, and aβ deposition in oldest-old cognitively unimpaired (cu) adults. ## Methods: A large sample of 139 cu older adults (mean age (range) = 85.4 (82-95)) underwent neuropsychological testing, pittsburgh compound-b (pib)-pet imaging and structural mri. hierarchical regression models examined associations between circulating inflammatory biomarkers (interleukin-6 (il-6), soluble tumor necrosis factor receptors 1 and 2 (stnfr1 and stnfr2), soluble cluster of differentiation 14 (scd14), c-reactive protein (crp)), cognition, and global and regional aβ deposition at baseline and over follow-up. indices of preclinical disease, including pathologic aβ status and hippocampal volume, were incorporated to assess conditional associations. ## Results: At baseline evaluation, higher concentrations of il-6 and stnfr2 were associated with greater global aβ burden in
Who reads Peripheral Inflammatory Biomarkers Predict the Deposition and Progression of Amyloid-β in Cognitively Unimpaired Older Adults?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Lauren E. Oberlin; Kirk I. Erickson; Rachel Mackey; William E. Klunk; Howard Aizenstein; Brian J. Lopresti; Lewis H. Kuller; Oscar L. Lopez; Beth E. Snitz
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)