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Avascular Femoral Head Necrosis in Pediatric Cancer Patients by Iftikhar Hanif; Hazem Mahmoud; Ching-Hon Pui is a Medicine article available to read on EtoBox.

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## Abstract Avascular femoral head necrosis was identified in 15 patients treated at a major pediatric oncology center from 1974 to 1991. The predominant underlying diagnosis was acute leukemia (lymphoblastic, __n__ = 6; non‐lymphoblastic, __n__ = 2); two patients had chronic myeloid leukemia, two Hodgkin's disease, and three other solid tumors. Patients ranged from 7 to 27 years of age at diagnosis of this complication, with a median interval of 25 months (range, 0–11 years) from primary diagnosis. Both steroids and radiation therapy appear implicated in the pathogenesis of avascular necrosis: nine patients had received high cumulative doses of prednisone (3.4–14 g/m^2^), four had received 35–64.8 Gy local irradiation involving the femoral head, and one underwent total body irradiation (12 Gy). Of the 11 surviving patients, six are asymptomatic and fully active. Two patients have joint pain that is responsive to conservative measures. Severe pain and joint deterioration necessitated arthroplasty in two cases, and a third child is undergoing orthopedic evaluation because of worsening symptoms. Thus, like adult cancer patients, children who receive high doses of steroids or local ir

Who reads Avascular Femoral Head Necrosis in Pediatric Cancer Patients?

Author

Iftikhar Hanif; Hazem Mahmoud; Ching-Hon Pui

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

1993

Language

EN

Field

Medicine (Health Sciences)