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Can I read The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton on EtoBox?
The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton by Inglebert, Mehdi; Locatelli, Laura; Tsvirkun, Daria; Sinha, Priti; Maier, Jeanette A.; Misbah, Chaouqi; Bureau, Lionel is a Engineering article available to read on EtoBox.
What is The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton about?
Reduced blood flow, as occurring in ischemia or resulting from exposure to microgravity such as encountered in space flights, induces a decrease in the level of shear stress sensed by endothelial cells forming the inner part of blood vessels. In the present study, we use a microvasculature-on-a-chip device in order to investigate the effect of such a reduction in shear stress on shear-adapted endothelial cells. We find that, within 1 h of exposition to reduced wall shear stress, human umbilical vein endothelial cells undergo reorganization of their actin skeleton with a decrease in the number of stress fibers and actin being recruited into the cells' peripheral band, indicating a fairly fast change in the cells' phenotype due to altered flow.
Who reads The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Inglebert, Mehdi; Locatelli, Laura; Tsvirkun, Daria; Sinha, Priti; Maier, Jeanette A.; Misbah, Chaouqi; Bureau, Lionel
- Publisher
- American Institute of Physics; AIP Publishing (ISSN 1932-1058)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)