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What is Distinct Lineages of Haemogenic Endothelium about?
This study investigates the distinct lineages of human definitive haemogenic endothelium (HE) and arterial vascular endothelium (VE) derived from human pluripotent stem cells (hPSCs). It demonstrates that HE, characterized by specific surface markers, undergoes a Notch-dependent endothelial-to-haematopoietic transition (EHT) to produce haematopoietic progenitors, while VE progenitors segregate into different populations. The findings provide insights into the signaling pathways regulating the specification
- Author
- Theodora Stougiannou
- Language
- EN