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Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy by Ahmed Tawfick; Marwa Matboli; Sara Shamloul; Sara H. A. Agwa; Maha Saad; Hassan Shaker; Mohamed M. Yassin Selim; Mohamed S. Salim; A. Radwan; A. A. Shorbagy; Waleed Mousa is a Medicine article available to read on EtoBox.

What is Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy about?

## Background Extracorporeal shock wave lithotripsy (ESWL) is considered one of the best choices for the treatment of various kinds of urinary tract calculi, although it might cause acute kidney injury. ## Objective To measure the urinary long non-coding RNA-messenger RNA (LncRNA-mRNA) panel before and after ESWL to evaluate post-ESWL renal injury in a reliable and non-invasive method. ## Patients and methods The study included 60 patients with renal stones treated with ESWL and 30 healthy volunteers. Voided urine samples were obtained before, 2 h, and 1 day after ESWL. We measured the urinary level of LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) by real-time qPCR and compared the results with serum creatinine and eGFR. ## Results LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were higher in patients with renal stones when compared with healthy volunteers. They showed a statistically significant increase in the level of LncRNA-mRNA panel in baseline and after ESWL treatment. ## Conclusion LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were significantly elevated following ESWL treatment, highlighting the usefulness of urinary biomarkers in identifying

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Author

Ahmed Tawfick; Marwa Matboli; Sara Shamloul; Sara H. A. Agwa; Maha Saad; Hassan Shaker; Mohamed M. Yassin Selim; Mohamed S. Salim; A. Radwan; A. A. Shorbagy; Waleed Mousa

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)