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The Effect of Prolactinoma on Tear Film Function by Cezmi Doğan; Ümit Yaşar Güleser; Oğuzhan Kılıçarslan; Burak Mergen; Özer Açbay; Güzin İskeleli is a Medicine article available to read on EtoBox.

What is The Effect of Prolactinoma on Tear Film Function about?

## Objectives: To compare dry eye parameters in prolactinoma patients and healthy controls and evaluate their correlation with prolactin (PRL) levels and the duration of hyperprolactinemia. ## Materials and Methods: Consecutive patients with prolactinoma and healthy controls were included in the study. Schirmer, tear break-up time (TBUT), tear osmolarity values, and ocular surface disease index (OSDI) scores were evaluated for each patient. Follow-up time and total duration of hyperprolactinemia were recorded for prolactinoma patients. ## Results: The study included 39 eyes of 39 patients with prolactinoma and 39 eyes of 39 age- and gender-matched healthy controls. Prolactinoma patients showed lower Schirmer (14.1±8.4 vs. 24.8±8.9 mm; p<0.001) and TBUT values (7.0±3.2 vs. 11.6±2.6 s; p<0.001) and higher OSDI scores (20.6±16.6 vs. 5.8±2.4; p<0.001) compared to the healthy controls. While the mean osmolarity of the prolactinoma patients was 301.6±8.3 mOsm/L, it was 297.7±12.5 mOsm/L for the healthy controls (p=0.07). The duration of hyperprolactinemia in prolactinoma patients showed a negative correlation with Schirmer (r=-0.395; p=0.013) and TBUT values (r=-0.377; p=0.018) and a pos

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Author

Cezmi Doğan; Ümit Yaşar Güleser; Oğuzhan Kılıçarslan; Burak Mergen; Özer Açbay; Güzin İskeleli

Published

2022

Field

Medicine (Health Sciences)