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A Comparison of the Clinical and Radiological Extent of Denosumab (Xgeva^®^) Related Osteonecrosis of the Jaw: A Retrospective Study by Assili, Zineb (author);Dolivet, Gilles (author);Salleron, Julia (author);Griffaton-Tallandier, Claire (author);Egloff-Juras, Claire (author);Phulpin, Bérengère (author) is a Medicine article available to read on EtoBox.

What is A Comparison of the Clinical and Radiological Extent of Denosumab (Xgeva^®^) Related Osteonecrosis of the Jaw: A Retrospective Study about?

Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive medication. The aim of this study was to evaluate the incidence of denosumab-related osteonecrosis of the jaw and to compare the clinical and radiological extent of osteonecrosis. A retrospective study of patients who received Xgeva^®^ at the Institut de Cancérologie de Lorraine (ICL) was performed. Patients for whom clinical and radiological (CBCT) data were available were divided into two groups: “exposed” for patients with bone exposure and “fistula” when only a fistula through which the bone could be probed was observed. The difference between clinical and radiological extent was assessed. The __p__-value was set at 0.05, and a total of 246 patients were included. The cumulative incidence of osteonecrosis was 0.9% at 6 months, 7% at 12 months, and 15% from 24 months. The clinical extent of MRONJ was significantly less than their radiological extent: in the “exposed” group, 17 areas (45%) were less extensive clinically than radiologically (__p__ < 0.001) and respectively 6 (67%) for the “fistula” group (__p__ < 0.031). It would seem that a CBCT is essential to know the real extent of MR

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Author
Assili, Zineb (author);Dolivet, Gilles (author);Salleron, Julia (author);Griffaton-Tallandier, Claire (author);Egloff-Juras, Claire (author);Phulpin, Bérengère (author)
Publisher
MDPI AG
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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