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1,3-AZOLES: Reactivity Towards E-Files by Luis Miguel Arellano Castellanos is a document available to read on EtoBox.

1. 1,2- and 1,3-azoles react with electrophiles at the nitrogen atoms through protonation and alkylation/acylation. Reactivity depends on the identity of the heteroatom (X = N, O, S). 2. 1,2-azoles react less readily than 1,3-azoles with electrophiles at nitrogen. Reaction at carbon is possible and activation/deactivation depends on the position and identity of heteroatoms. 3. Key reactions include cycloadditions, carbonyl condensations to form rings, and deprotonation/metallation at nitrogen followed by

Author

Luis Miguel Arellano Castellanos

Language

EN