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Synthesis and Evaluation of 2-Pyridyl Pyrimidines with in Vitro Antiplasmodial and Antileishmanial Activity by Chitalu C. Musonda; Gavin A. Whitlock; Michael J. Witty; Reto Brun; Marcel Kaiser is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and Evaluation of 2-Pyridyl Pyrimidines with in Vitro Antiplasmodial and Antileishmanial Activity about?
A series of 2-pyridyl pyrimidines, reported inhibitors of Plasmodium falciparum methionine aminopeptidase 1b were synthesized and evaluated for their antiplasmodial activities. An analysis of physicochemical properties demonstrated a link between lipophilicity and antiparasitic activity. Cross screening of the library against cultured Leishmania donovani parasites revealed this class of compounds as potent inhibitors of parasite development in vitro.
Who reads Synthesis and Evaluation of 2-Pyridyl Pyrimidines with in Vitro Antiplasmodial and Antileishmanial Activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Chitalu C. Musonda; Gavin A. Whitlock; Michael J. Witty; Reto Brun; Marcel Kaiser
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)