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GABAergic and glycinergic synapses onto neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats: light and electron microscopic studies by Ying-Ying Liu; Margaret T. T. Wong-Riley; Jin-Ping Liu; Yi Jia; Hui-Ling Liu; Xi-Ying Jiao; And Gong Ju is a Neuroscience article available to read on EtoBox.

What is GABAergic and glycinergic synapses onto neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats: light and electron microscopic studies about?

## Abstract The pre‐Bötzinger complex (preBötC) in the ventrolateral medulla is thought to be the kernel for respiratory rhythm generation. Neurons in the preBötC contain intense neurokinin‐1 receptor (NK1R) immunoreactivity. Some of these neurons in the adult preBötC are presumed to be the pre‐inspiratory interneurons that are essential for generating respiratory rhythm in the neonate. Chloride‐mediated synaptic inhibition is critical for rhythmogenesis in the adult. The present study used immunofluorescence histochemistry and immunogold‐silver staining to determine the inhibitory synaptic relationship between glutamic acid decarboxylase (GAD)‐ or glycine transporter 2 (GlyT2)‐immunoreactive (ir) boutons and NK1R‐ir neurons in the preBötC of adult rats. Under the confocal microscope, we found that GAD‐ and GlyT2‐ir boutons were in close apposition to NK1R‐ir somas and dendrites in the preBötC. Under the electron microscope, GAD‐ and GlyT2‐ir terminals were in close apposition to NK1R‐ir somas and dendrites. Symmetric synapses were identified between GAD‐ or GlyT2‐ir terminals and NK1R‐ir neurons. A total of 51.6% GAD‐ir and 38.2% GlyT2‐ir terminals were found to contact or make sy

Who reads GABAergic and glycinergic synapses onto neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats: light and electron microscopic studies?

Author

Ying-Ying Liu; Margaret T. T. Wong-Riley; Jin-Ping Liu; Yi Jia; Hui-Ling Liu; Xi-Ying Jiao; And Gong Ju

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)