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Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer by Caterina Peraldo-Neia; Giorgia Migliardi; Maurizia Mello-Grand; Filippo Montemurro; Raffaella Segir; Ymera Pignochino; Giuliana Cavalloni; Bruno Torchio; Luciano Mosso; Giovanna Chiorino; Massimo Aglietta is a Medicine article available to read on EtoBox.

What is Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer about?

Background: Activating mutations of the epidermal growth factor receptor (EGFR) confer sensitivity to the tyrosine kinase inhibitors (TKi), gefitinib and erlotinib. We analysed EGFR expression, EGFR mutation status and gene expression profiles of prostate cancer (PC) to supply a rationale for EGFR targeted therapies in this disease. Methods: Mutational analysis of EGFR TK domain (exons from 18 to 21) and immunohistochemistry for EGFR were performed on tumour tissues derived from radical prostatectomy from 100 PC patients. Gene expression profiling using oligo-microarrays was also carried out in 51 of the PC samples. Results: EGFR protein overexpression (EGFR high ) was found in 36% of the tumour samples, and mutations were found in 13% of samples. Patients with EGFR high tumours experienced a significantly increased risk of biochemical relapse (hazard ratio-HR 2.52, p=0.02) compared with patients with tumours expressing low levels of EGFR (EGFR low ). Microarray analysis did not reveal any differences in gene expression between EGFR high and EGFR low tumours. Conversely, in EGFR high tumours, we were able to identify a 79 gene signature distinguishing mutated from non-mutated tumou

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Author

Caterina Peraldo-Neia; Giorgia Migliardi; Maurizia Mello-Grand; Filippo Montemurro; Raffaella Segir; Ymera Pignochino; Giuliana Cavalloni; Bruno Torchio; Luciano Mosso; Giovanna Chiorino; Massimo Aglietta

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)

Published

2011

Language

EN

ISBN

9781471240713

Field

Medicine (Health Sciences)