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Advances in Analysis of Transcriptional Regulatory Networks by Tae-Min Kim; Peter J. Park is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract A transcriptional regulatory network represents a molecular framework in which developmental or environmental cues are transformed into differential expression of genes. Transcriptional regulation is mediated by the combinatorial interplay between __cis__‐regulatory DNA elements and __trans__‐acting transcription factors, and is perhaps the most important mechanism for controlling gene expression. Recent innovations, most notably the method for detecting protein–DNA interactions genome‐wide, can help provide a comprehensive catalog of __cis__‐regulatory elements and their interaction with given __trans__‐acting factors in a given condition. A transcriptional regulatory network that integrates such information can lead to a systems‐level understanding of regulatory mechanisms. In this review, we will highlight the key aspects of current knowledge on eukaryotic transcriptional regulation, especially on known transcription factors and their interacting regulatory elements. Then we will review some recent technical advances for genome‐wide mapping of DNA–protein interactions based on high‐throughput sequencing. Finally, we will discuss the types of biological insights that

Who reads Advances in Analysis of Transcriptional Regulatory Networks?

Author

Tae-Min Kim; Peter J. Park

Publisher

Wiley (John Wiley & Sons); John Wiley and Sons Inc.; Wiley (ISSN 1939-5094)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)