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Prevalence of eosinophilic, atopic, and overlap phenotypes among patients with severe asthma in Saudi Arabia: a cross-sectional study by Al-Jahdali, Hamdan (author);Wali, Siraj (author);Albanna, Amr S. (author);Allehebi, Riyad (author);Al-Matar, Hussein (author);Fattouh, Mohamed (author);Beekman, Maarten (author) is a Medicine article available to read on EtoBox.
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## Abstract ## Background Eosinophilia is a significant factor in asthma severity; however, the prevalence of severe eosinophilic asthma in Saudi Arabia is largely unknown. We aimed to determine the prevalence of the eosinophilic (defined in this study as ≥ 300 cells/mm^3^ in blood), atopic (atopic phenotype 1, defined in this study as > 100 IU/mL total serum IgE; atopic phenotype 2, defined in this study as > 150 IU/mL), and overlap phenotypes among patients with severe asthma in Saudi Arabia. ## Methods A cross-sectional study was conducted in centers specialized in severe asthma management. Patients aged ≥ 12 years with severe asthma were enrolled. Study patients responded to the Global Initiative for Asthma 2018 assessment of asthma control questionnaire and provided study investigators with current information related to the study objectives. Additional medical record data and a blood sample for total serum IgE and complete blood count were collected. ## Results A total of 101 patients were enrolled; 83% were female and the mean (standard deviation) age was 48.7 (13.2) years. Forty-five (45%) patients had the eosinophilic phenotype, 50 (50%) had atopic phenotype 1, and 25 (25%
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- Author
- Al-Jahdali, Hamdan (author);Wali, Siraj (author);Albanna, Amr S. (author);Allehebi, Riyad (author);Al-Matar, Hussein (author);Fattouh, Mohamed (author);Beekman, Maarten (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)