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Can I read Efficacy of Topotecan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma on EtoBox?
Efficacy of Topotecan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma by Elham Delrish; Mahmoud Jabbarvand; Fariba Ghassemi; Fahimeh Asadi Amoli; Fatemeh Atyabi; Alireza Lashay; Masoud Soleimani; Leila Aghajanpour; Rassoul Dinarvand is a Medicine article available to read on EtoBox.
What is Efficacy of Topotecan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma about?
Retinoblastoma (Rb) is the most common intraocular malignancy in children that accounts for approximately 4% of all pediatric malignancies. Since chemotherapy is a widely practiced treatment for Rb, there is a growing interest in developing new and effective drugs to overcome systemic and local side effects of chemotherapy to improve the quality of life and increase the chances of survival. This study sought to fabricate thiolated chitosan nanoparticles containing topotecan (TPH-TCs-NPs) with a view of enhancing drug loading and release control. This research was also designed to assess the ability of TPH-TCs-NPs to improve cell association, increase treatment efficacy in retinoblastoma cells and xenograft-rat-model of retinoblastoma, and overcome current topotecan hydrochloride (TPH) intravitreal administration challenges, including stability loss and poor cellular uptake. Modified ionic gelation method was optimized to fabricate TPH-TCs-NPs and TPH-TMC-NPs (N-trimethyl chitosan nanoparticles containing TPH). We characterized the NPs and quantified topotecan loading and release against a free TPH standard. The efficacy of TPH-NPs was quantified in human retinoblastoma cells (Y79)
Who reads Efficacy of Topotecan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Elham Delrish; Mahmoud Jabbarvand; Fariba Ghassemi; Fahimeh Asadi Amoli; Fatemeh Atyabi; Alireza Lashay; Masoud Soleimani; Leila Aghajanpour; Rassoul Dinarvand
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)