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Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS) by Pia Johansson Heinsvig; Carolina Noble; Petur Weihe Dalsgaard; Marie Mardal is a Chemistry article available to read on EtoBox.

What is Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS) about?

Liquid chromatography-high resolution mass spectrometry (LC-HRMS) has been widely used for screening small organic molecules in complex samples. Its selectivity and sensitivity allow for broad-scope screening of thousands of analytes. However, the complexity of the acquired data has complicated its implementation in high-throughput laboratories that analyze hundreds of samples per week and require that multiple users be able to analyze the data. Forensic laboratories have managed to harvest the merits of LC-HRMS technology using robust and often leveled data analysis(/acquisition) workflows, without spending a disproportionate amount of time evaluating inconclusive or false positive identifications. This critical review describes the full analytical process of LC-HRMS-based forensic drug screening, from sample preparation to data analysis and beyond. Interesting solutions are highlighted, and two emerging trends will be discussed: i) the use of free online tools to improve forensic drug screening, and ii) re-use of data to improve forensic services.

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Author

Pia Johansson Heinsvig; Carolina Noble; Petur Weihe Dalsgaard; Marie Mardal

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)