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Longitudinal association of anthropometry with mammographic breast density in the Study of Women's Health Across the Nation by Katherine W. Reeves; Roslyn A. Stone; Francesmary Modugno; Roberta B. Ness; Victor G. Vogel; Joel L. Weissfeld; Laurel A. Habel; Barbara Sternfeld; Jane A. Cauley is a Medicine article available to read on EtoBox.
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## Abstract High percent mammographic breast density is strongly associated with increased breast cancer risk. Though body mass index (BMI) is positively associated with risk of postmenopausal breast cancer, BMI is negatively associated with percent breast density in cross‐sectional studies. Few longitudinal studies have evaluated associations between BMI and weight and mammographic breast density. We studied the longitudinal relationships between anthropometry and breast density in a prospective cohort of 834 pre‐ and perimenopausal women enrolled in an ancillary study to the Study of Women's Health Across the Nation (SWAN). Routine screening mammograms were collected and read for breast density. Random intercept regression models were used to evaluate whether annual BMI change was associated with changes over time in dense breast area and percent density. The study population was 7.4% African‐American, 48.8% Caucasian, 21.8% Chinese, and 21.9% Japanese. Mean follow‐up was 4.8 years. Mean annual weight change was +0.32 kg/year, mean change in dense area was −0.77 cm^2^/year, and mean change in percent density was ‐1.14%/year. In fully adjusted models, annual change in BMI was not
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- Author
- Katherine W. Reeves; Roslyn A. Stone; Francesmary Modugno; Roberta B. Ness; Victor G. Vogel; Joel L. Weissfeld; Laurel A. Habel; Barbara Sternfeld; Jane A. Cauley
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)