Can I read Asymmetric Michael Addition of Unactivated Ketones with Î2âNitrostyrenes Mediated by Bifunctional LâProlinamide Organocatalysts on EtoBox?

Asymmetric Michael Addition of Unactivated Ketones with Î2âNitrostyrenes Mediated by Bifunctional LâProlinamide Organocatalysts by Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti is a Chemistry article available to read on EtoBox.

What is Asymmetric Michael Addition of Unactivated Ketones with Î2âNitrostyrenes Mediated by Bifunctional LâProlinamide Organocatalysts about?

## Abstract The catalytic activity of two types of L‐prolinamide organocatalysts was investigated for asymmetric Michael addition reaction of cyclic/acyclic ketones with β‐nitrostyrens. L‐Prolinamides bearing amino groups on phenyl ring worked well, though their catalytic efficiency as well as selectivity was found to be dependent upon the position of amine group to the amide bond. Organocatalyst having –NH~2~ group ortho to amide bond provided the best results. Substrate scope was also studied by performing the reaction of various β‐nitrostyrenes with ketones to afford the corresponding Michael adducts in excellent yields with very high diastereoselectivities and enantioselectivities in almost all cases.

Who reads Asymmetric Michael Addition of Unactivated Ketones with Î2âNitrostyrenes Mediated by Bifunctional LâProlinamide Organocatalysts?

Author

Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti

Publisher

Wiley (John Wiley & Sons); Wiley-Blackwell Publishing Ltd; Wiley (ISSN 2365-6549)

Published

2020

Language

EN

Field

Chemistry (Physical Sciences)