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Can I read Glycosidation, 14. Stereoselective synthesis of acetal-β-glucosides by reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose with enol ethers on EtoBox?
Glycosidation, 14. Stereoselective synthesis of acetal-β-glucosides by reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose with enol ethers by Lutz F. Tietze; Michael Lögers is a Chemistry article available to read on EtoBox.
What is Glycosidation, 14. Stereoselective synthesis of acetal-β-glucosides by reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose with enol ethers about?
## Abstract Acetal‐glycosides are a new class of compounds which is of interest in the development of selective anticancer agents. Cytotoxic aldehydes and ketones may be released by enzymatic or acid‐catalyzed hydrolysis preferentially in the tumour tissue. An alternative synthetic route to acetal‐β‐glucosides 4 was developed in connection with these investigations. The acetyl‐protected acetal‐β‐glucosides 3a–h are obtained anomerically pure in 63–95% yield by reaction of 2,3,4,6‐tetra‐__O__‐acetyl‐β‐D‐glucopyranose (1) with an enol ether 2a–h in the presence of catalytic amounts of __p__‐toluenesulfonic acid in dry tetrahydrofuran at room temperature. Deacetylation with potassium carbonate in methanol gives the free acetal‐β‐glucosides 4a–h.
Who reads Glycosidation, 14. Stereoselective synthesis of acetal-β-glucosides by reaction of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose with enol ethers?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Lutz F. Tietze; Michael Lögers
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); VCH Verlagsgesellschaft; Wiley (ISSN 0947-3440)
- Published
- 1990
- Language
- EN
- Field
- Chemistry (Physical Sciences)