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Structure of insect-cell-derived IL-22 by Ting Xu; Naomi J. Logsdon; Mark R. Walter is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Structure of insect-cell-derived IL-22 about?

The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.

Who reads Structure of insect-cell-derived IL-22?

Author

Ting Xu; Naomi J. Logsdon; Mark R. Walter

Publisher

International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr) (ISSN 0907-4449)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)