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CAA-derived IL-6 induced M2 macrophage polarization by activating STAT3 by Zhao, Chongru (author);Zeng, Ning (author);Zhou, Xiaomei (author);Tan, Yufang (author);Wang, Yichen (author);Zhang, Jun (author);Wu, Yiping (author);Zhang, Qi (author) is a Medicine article available to read on EtoBox.

What is CAA-derived IL-6 induced M2 macrophage polarization by activating STAT3 about?

## Background Tumor-associated macrophages (TAMs) are the most abundant types of immune cells in the tumor microenvironment (TME) of breast cancer (BC). TAMs usually exhibit an M2 phenotype and promote tumor progression by facilitating immunosuppression. This study aimed to investigate the effect of CAA-derived IL-6 on macrophage polarization in promoting BC progression. ## Methods Human BC samples and adipocytes co-cultured with 4T1 BC cells were employed to explore the properties of CAAs. The co-implantation of adipocytes and 4T1 cells in mouse tumor-bearing model and tail vein pulmonary metastasis model were constructed to investigate the impact of CAAs on BC malignant progression in vivo. The functional assays, qRT-PCR, western blotting assay and ELISA assay were employed to explore the effect of CAA-derived IL-6 on macrophage polarization and programmed cell death protein ligand 1 (PD-L1) expression. ## Results CAAs were located at the invasive front of BC and possessed a de-differentiated fibroblast phenotype. CAAs facilitated the malignant behaviors of 4T1 cells in vitro, and promoted 4T1 tumor growth and pulmonary metastasis in vivo. The IHC staining of both human BC specim

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Author
Zhao, Chongru (author);Zeng, Ning (author);Zhou, Xiaomei (author);Tan, Yufang (author);Wang, Yichen (author);Zhang, Jun (author);Wu, Yiping (author);Zhang, Qi (author)
Publisher
Springer Science and Business Media LLC
Published
2023
Language
EN
Field
Medicine (Health Sciences)

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