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This study investigates the role of the G-protein subunit Gi!2 in the release of arachidonate and production of prostaglandin E2 (PGE2) in intestinal and colonic myofibroblasts. Mice deficient in Gi!2 exhibit significantly reduced levels of PGE2 and arachidonate, leading to increased susceptibility to colitis and colon cancer. The findings highlight the importance of Gi!2 signaling in maintaining myofibroblast function and the anti-inflammatory role of PGE2 in the gut mucosa.

Author

tbseek63

Language

EN