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Long‐term sustained benefits of clozapine treatment in refractory early onset schizophrenia: A retrospective study in Korean children and adolescents by Yeni Kim; Boong‐Nyun Kim; Soo‐Churl Cho; Jae‐Won Kim; Min‐Sup Shin is a Medicine article available to read on EtoBox.

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## Abstract Objective: Treatment resistance in early onset schizophrenia (EOS) is one of the most challenging problems in child and adolescent psychiatry. We retrospectively examined the therapeutic dosage, clinical response, and side effect profiles of long‐term clozapine treatment in Korean children and adolescents with refractory EOS or very early onset schizophrenia (VEOS). Method: 26 refractory patients treated with clozapine for more than 1 year were analyzed. Efficacy was determined by comparing hospitalization rate and duration, before and after clozapine treatment. Tolerability was assessed through review of documented adverse events. Results: A significant reduction in __hospital days per year__ was observed in 25 (96.2%) patients after clozapine treatment compared to before clozapine. Long‐term benefit of the treatment was supported by a further reduction of the hospitalization rate in 14 patients treated with clozapine for more than 3 years. Neutropenia developed in 26.9% patients at 1 year and there was no agranulocytosis. Overall, eight male patients (8/12, 66.7%) and one female patient (1/14, 7%) developed neutropenia and out of the nine patients, seven patients were

Who reads Long‐term sustained benefits of clozapine treatment in refractory early onset schizophrenia: A retrospective study in Korean children and adolescents?

Author

Yeni Kim; Boong‐Nyun Kim; Soo‐Churl Cho; Jae‐Won Kim; Min‐Sup Shin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-6222)

Published

2008

Language

EN

Field

Medicine (Health Sciences)