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The article investigates how sugars, particularly trehalose, protect protein structures during desiccation, which is crucial for the stability of protein-based drugs. Using techniques like LOVE NMR, DSC, and TGA, the study reveals that sugars enhance intraprotein hydrogen bonding and vitrification, while water retention is not a significant factor. The findings suggest that trehalose is the most effective sugar for maintaining protein stability due to its covalent stability.
- Author
- pakdekro
- Language
- EN