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Impact of Strut Dimensions and Vessel Caliber on Thrombosis Risk of Bioresorbable Scaffolds Using Hemodynamic Metrics by Michael Stiehm; Carolin Wüstenhagen; Stefan Siewert; Hüseyin Ince; Niels Grabow; Klaus-Peter Schmitz is a Medicine article available to read on EtoBox.
What is Impact of Strut Dimensions and Vessel Caliber on Thrombosis Risk of Bioresorbable Scaffolds Using Hemodynamic Metrics about?
Bioresorbable scaffolds (BRS) promise to be the treatment of choice for stenosed coronary vessels. But higher thrombosis risk found in current clinical studies limits the expectations. Three hemodynamic metrics are introduced to evaluate the thrombosis risk of coronary stents/scaffolds using transient computational fluid dynamics (CFD). The principal phenomena are platelet activation and effective diffusion (platelet shear number, PSN), convective platelet transport (platelet convection number, PCN) and platelet aggregation (platelet aggregation number, PAN) were taken into consideration. In the present study, two different stent designs (thick-strut vs. thin-strut design) positioned in small-and mediumsized vessels (reference vessel diameter, RVD = 2.25 mm vs. 2.70 mm) were analyzed. In both vessel models, the thick-strut design induced higher PSN, PCN and PAN values than the thin-strut design (thick-strut vs. thin-strut: PSN = 2.92/2.19 and 0.54/0.30; PCN = 3.14/1.15 and 2.08/0.43; PAN: 14.76/8.19 and 20.03/10.18 for RVD = 2.25 mm and 2.70 mm). PSN and PCN are increased by the reduction of the vessel size (PSN: RVD = 2.25 mm vs. 2.70 mm = 5.41 and 7.30; PCN: RVD = 2.25 mm vs. 2.7
Who reads Impact of Strut Dimensions and Vessel Caliber on Thrombosis Risk of Bioresorbable Scaffolds Using Hemodynamic Metrics?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Michael Stiehm; Carolin Wüstenhagen; Stefan Siewert; Hüseyin Ince; Niels Grabow; Klaus-Peter Schmitz
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)