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Combined Role of Tumor Angiogenesis, Bcl-2, and P53 Expression in the Prognosis of Patients with Colorectal Carcinoma by Alexandra Giatromanolaki; George P. Stathopoulos; Eleni Tsiobanou; Costandina Papadimitriou; Vassilios Georgoulias; Kevin C. Gatter; Adrian L. Harris; Michael I. Koukourakis is a Medicine article available to read on EtoBox.
What is Combined Role of Tumor Angiogenesis, Bcl-2, and P53 Expression in the Prognosis of Patients with Colorectal Carcinoma about?
BACKGROUND. The objective of this study was to evaluate intratumoral neoangiogenesis in Dukes Stage B and Stage C (AJCC/UICC Stage I and III) colorectal adenocarcinoma and its correlation with nuclear p53 oncoprotein accumulation and cytoplasmic bcl-2 expression as well as to assess the prognostic significance of these features in patient outcome. METHODS. Paraffin embedded specimens from 55 patients with Dukes Stage B (AJCC/UICC Stage I) and 51 patients with Dukes Stage C (AJCC/UICC Stage III) colorectal adenocarcinoma who were treated with surgery were assessed. Patients with lymph node involvement (Dukes Stage C [AJCC/UICC Stage III]) also were treated with postoperative pelvic radiotherapy and adjuvant chemotherapy with 5-fluorouracil and leucovorin with or without interferon-␣. Immunohistochemistry was performed using the anti-CD31 monoclonal antibody (MoAb) for vessel staining, the DO7 MoAb for nuclear p53 expression, and the clone 124 for cytoplasmic/ perinuclear bcl-2 expression. Patient follow-up ranged from 4 -70 months (median, 28 months).
Who reads Combined Role of Tumor Angiogenesis, Bcl-2, and P53 Expression in the Prognosis of Patients with Colorectal Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alexandra Giatromanolaki; George P. Stathopoulos; Eleni Tsiobanou; Costandina Papadimitriou; Vassilios Georgoulias; Kevin C. Gatter; Adrian L. Harris; Michael I. Koukourakis
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)