Opening book details…
Can I read Microbiome Modulation After Severe Acute Kidney Injury Accelerates Functional Recovery and Decreases Kidney Fibrosis on EtoBox?
Microbiome Modulation After Severe Acute Kidney Injury Accelerates Functional Recovery and Decreases Kidney Fibrosis by Sepideh Gharaie; Kyungho Lee; Andrea M. Newman-Rivera; Jiaojiao Xu; Shishir Kumar Patel; Mahta Gooya; Lois J. Arend; Dominic S. Raj; Jennifer Pluznick; Chirag Parikh; Sanjeev Noel; Hamid Rabb is a Medicine article available to read on EtoBox.
What is Microbiome Modulation After Severe Acute Kidney Injury Accelerates Functional Recovery and Decreases Kidney Fibrosis about?
Targeting gut microbiota has shown promise to prevent experimental acute kidney injury (AKI). However, this has not been studied in relation to accelerating recovery and preventing fibrosis. Here, we found that modifying gut microbiota with an antibiotic administered after severe ischemic kidney injury in mice, particularly with amoxicillin, accelerated recovery. These indices of recovery included the glomerular filtration rate, diminution of kidney fibrosis, and reduction of kidney profibrotic gene expression. Amoxicillin was found to increase stool Alistipes, Odoribacter and Stomatobaculum species while significantly depleting Holdemanella and Anaeroplasma. Specifically, amoxicillin treatment reduced kidney CD4+T cells, interleukin (IL)-17 +CD4+T cells, and tumor necrosis factor-α double negative T cells while it increased CD8+T cells and PD1+CD8+T cells. Amoxicillin also increased gut lamina propria CD4+T cells while decreasing CD8+T and IL-17+CD4+T cells. Amoxicillin did not accelerate repair in germ-free or CD8-deficient mice, demonstrating microbiome and CD8+T lymphocytes dependence for amoxicillin protective effects. However, amoxicillin remained effective in CD4-deficient m
Who reads Microbiome Modulation After Severe Acute Kidney Injury Accelerates Functional Recovery and Decreases Kidney Fibrosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sepideh Gharaie; Kyungho Lee; Andrea M. Newman-Rivera; Jiaojiao Xu; Shishir Kumar Patel; Mahta Gooya; Lois J. Arend; Dominic S. Raj; Jennifer Pluznick; Chirag Parikh; Sanjeev Noel; Hamid Rabb
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)