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Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial by Nicolas Verheyen; Andreas Meinitzer; Martin Robert Grübler; Klemens Ablasser; Ewald Kolesnik; Astrid Fahrleitner-Pammer; Evgeny Belyavskiy; Christian Trummer; Verena Schwetz; Elisabeth Pieske-Kraigher; Jakob Voelkl; Ioana Alesutan; Cristiana Catena; Leonardo Alberto Sechi; Helmut Brussee; Dirk von Lewinski; Winfried März; Burkert Pieske; Stefan Pilz; Andreas Tomaschitz is a Medicine article available to read on EtoBox.

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## Background: Primary hyperparathyroidism (phpt) is associated with low-grade inflammation, left ventricular hypertrophy and increased cardiovascular mortality, but the association between inflammatory markers and parameters of adverse cardiac remodeling is unknown. we investigated the relationship between c-reactive protein (crp), the essential amino acid tryptophan and its pro-inflammatory derivatives kynurenine and quinolinic acid (quin) with echocardiographic parameters. ## Methods: Cross-sectional baseline data from the "eplerenone in primary hyperparathyroidism" trial were analyzed. patients with any acute illness were excluded. we assessed associations between crp, serum levels of tryptophan, kynurenine and quin and left ventricular mass index (lvmi), left atrial volume index (lavi) and e/e'. ## Results: Among 136 subjects with phpt (79% females), 100 (73%) had arterial hypertension and the prevalence of left ventricular hypertrophy was 52%. multivariate linear regression analyses with lvmi, lavi and e/e' as respective dependent variables, and c-reactive protein and tryptophan, kynurenine and quin as respective independent variables were performed. analyses were adjusted fo

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Author

Nicolas Verheyen; Andreas Meinitzer; Martin Robert Grübler; Klemens Ablasser; Ewald Kolesnik; Astrid Fahrleitner-Pammer; Evgeny Belyavskiy; Christian Trummer; Verena Schwetz; Elisabeth Pieske-Kraigher; Jakob Voelkl; Ioana Alesutan; Cristiana Catena; Leonardo Alberto Sechi; Helmut Brussee; Dirk von Lewinski; Winfried März; Burkert Pieske; Stefan Pilz; Andreas Tomaschitz

Publisher

Walter de Gruyter GmbH

Published

2017

Language

EN

Field

Medicine (Health Sciences)