About this Medicine article
The Mean Radiation Dose in Pharyngheal Structures is a Strong Predictor of Acute and Persistent Swallowing Dysfunction and Quality of Life in Head and Neck Radiotherapy by P. Doornaert; B.J. Slotman; D.H.F. Rietveld; C.R. Leemans; J.A. Langendijk is a Medicine article available to read on EtoBox.
hypopharynx were significantly higher in the group with severe late toxicity (p = 0.015 and p = 0.025, respectively). On multivariate analysis, the only statistically significant covariates associated with severe late toxicity were age (odds ratio 1.062; p = 0.002) and dose to the inferior hypopharynx (odds ratio 1.023; p = 0.016) (both analyzed as continuous variables). The median inferior hypopharynx dose among pts with severe late toxicity (cases) was 58 Gy, compared with 50.6 Gy among pts without severe late toxicity (controls). Conclusions: Higher dose to the inferior hypopharynx is associated with a greater risk of severe late toxicity among pts treated with CCRT for head and neck cancer. More detailed and rigorous dose-volume analyses based on 3-D/IMRT datasets are required, both to confirm this finding and to elucidate future means of decreasing late radiation complications.
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- P. Doornaert; B.J. Slotman; D.H.F. Rietveld; C.R. Leemans; J.A. Langendijk
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)