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Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents by Zeyi Sun; Tieyan Li; Tianxiao Mei; Yang Liu; Kerui Wu; Wenjun Le; Yihui Hu is a Materials Science article available to read on EtoBox.

What is Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents about?

Metal-organic frameworks (MOFs) hold great promise for widespread applications in biomedicine and nanomedicine. MOFs are one of the most fascinating nanocarriers for drug delivery, benefiting from their high porosity and facile modification. Furthermore, the tailored components of MOFs can be therapeutic agents for various treatments, including drugs as organic ligands of MOFs, active metal as central metal ions of MOFs, and their combinations as carrier-free MOF-based nanodrug. In this review, the advances in delivery systems and applications as therapeutic agents for nanoscale MOF-based materials are summarized. The challenges of MOFs in clinical translation and the future directions in the field of MOFs therapy are also discussed. We hope that more researchers will focus their attention on advancing and translating MOF-based nanodrugs into pre-clinical and clinical applications. ## MOFs as delivery systems MOFs, as an inorganic-organic hybrid nanocarrier, hold its intrinsic advantages over inorganic and organic carriers, owing

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Author

Zeyi Sun; Tieyan Li; Tianxiao Mei; Yang Liu; Kerui Wu; Wenjun Le; Yihui Hu

Publisher

Royal Society of Chemistry (RSC)

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)