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Impact of COVID‐19 infection and vaccination in pancreatobiliary IgG4‐related disease patients: An international multicenter study by Raymond S Y Tang; Onuma Sattayalertyanyong; Yu‐Ting Kuo; Kenneth H Park; Constantinos Anastassiades; Dario Ligresti; Nobuhiko Hayashi; Aws Hasan; Tae‐Hyeon Kim; Nonthalee Pausawasdi; Hsiu‐Po Wang; Simon K Lo; Khek‐Yu Ho; Luca Barresi; Mario Traina; Ichiro Yasuda; Thomas J Savides; Chieh‐Sian Koo; Ting Ting Chan; Thomas Y T Lam; Joseph J Y Sung is a Medicine article available to read on EtoBox.

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Background and Aim: Dedicated studies evaluating the impact of COVID-19 on outcomes of pancreatobiliary IgG4 related disease (IgG4-RD) patients are scarce. Whether COVID-19 infection or vaccination would trigger IgG4-RD exacerbation remains unknown. Methods: Pancreatobiliary IgG4-RD patients ≥ 18 years old with active follow-up since January 2020 from nine referral centers in Asia, Europe, and North America were included in this multicenter retrospective study. Outcome measures include incidence and severity of COVID-19 infection, IgG4-RD disease activity and treatment status, interruption of indicated IgG4-RD treatment. Prospective data on COVID-19 vaccination status and new COVID-19 infection during the Omicron outbreak were also retrieved in the Hong Kong cohort. Results: Of the 124 pancreatobiliary IgG4-RD patients, 25.0% had active IgG4-RD, 71.0% were on immunosuppressive therapies and 80.6% had ≥ 1 risk factor for severe COVID. In 2020 (pre-vaccination period), two patients (1.6%) had COVID-19 infection (one requiring ICU admission), and 7.2% of patients had interruptions in indicated immunosuppressive treatment for IgG4-RD. Despite a high vaccination rate (85.0%), COVID-19 i

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Author

Raymond S Y Tang; Onuma Sattayalertyanyong; Yu‐Ting Kuo; Kenneth H Park; Constantinos Anastassiades; Dario Ligresti; Nobuhiko Hayashi; Aws Hasan; Tae‐Hyeon Kim; Nonthalee Pausawasdi; Hsiu‐Po Wang; Simon K Lo; Khek‐Yu Ho; Luca Barresi; Mario Traina; Ichiro Yasuda; Thomas J Savides; Chieh‐Sian Koo; Ting Ting Chan; Thomas Y T Lam; Joseph J Y Sung

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)