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Adsorption of Collagen Nanofibrils on Rough TiO2: A Molecular Dynamics Study by Wenke Friedrichs; Bastian Ohler; Walter Langel; Susanna Monti; Susan Köppen is a Engineering article available to read on EtoBox.

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An atomistic picture of the biointerface between titanium oxide surfaces and proteins of the extracellular matrix is essential for understanding the initial steps for incorporation of titanium-based medical implants into physiological tissues in detail. The physicochemical properties of the TiO x /collagen interface essentially determine the biocompatibility, and specific protein coatings like collagen can dramatically enhance the growth of new bone tissue. [1,2] Protein adsorption on aqueous titania [2][3][4] and material surfaces in general [5][6][7] has recently been investigated in several experiments. Real surfaces are usually rough and can be described by steps, terraces, and vacancies. [8,9] Surface roughness from the macroscopic down to nanometer scale can influence protein adsorption. [4][5][6] Whereas the amount of collagen adsorbed on polymer surfaces with roughness in the range from 5 to 40 A ̊was nearly constant, significant differences in the morphology of the adsorbate were observed. [6] A number of theoretical investigations focused on the peptide surface interaction at an atomistic level, [10][11][12][13][14][15] and included adsorption of dipeptides, [10] and oth

Who reads Adsorption of Collagen Nanofibrils on Rough TiO2: A Molecular Dynamics Study?

Author

Wenke Friedrichs; Bastian Ohler; Walter Langel; Susanna Monti; Susan Köppen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1438-1656)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)