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Can I read Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice on EtoBox?
Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice by Ilya A. Demyanenko; Ekaterina N. Popova; Vlada V. Zakharova; Olga P. Ilyinskaya; Tamara V. Vasilieva; Valeria P. Romashchenko; Artem V. Fedorov; Vasily N. Manskikh; Maxim V. Skulachev; Roman A. Zinovkin; Olga Yu. Pletjushkina; Vladimir P. Skulachev; Boris V. Chernyak is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice about?
The process of skin wound healing is delayed or impaired in aging animals. To investigate the possible role of mitochondrial reactive oxygen species (mtROS) in cutaneous wound healing of aged mice, we have applied the mitochondria-targeted antioxidant SkQ1. The SkQ1 treatment resulted in accelerated resolution of the inflammatory phase, formation of granulation tissue, vascularization and epithelization of the wounds. The wounds of SkQ1-treated mice contained increased amount of myofibroblasts which produce extracellular matrix proteins and growth factors mediating granulation tissue formation. This effect resembled SkQ1-induced differentiation of fibroblasts to myofibroblast, observed earlier __in vitro__. The Transforming Growth Factor beta (TGFβ)produced by SkQ1-treated fibroblasts was found to stimulated motility of endothelial cells __in vitro__, an effect which may underlie pro-angiogenic action of SkQ1 in the wounds. __In vitro__ experiments showed that SkQ1 prevented decomposition of VE-cadherin containing contacts and following increase in permeability of endothelial cells monolayer, induced by pro-inflammatory cytokine TNF. Prevention of excessive reaction of endothelium
Who reads Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ilya A. Demyanenko; Ekaterina N. Popova; Vlada V. Zakharova; Olga P. Ilyinskaya; Tamara V. Vasilieva; Valeria P. Romashchenko; Artem V. Fedorov; Vasily N. Manskikh; Maxim V. Skulachev; Roman A. Zinovkin; Olga Yu. Pletjushkina; Vladimir P. Skulachev; Boris V. Chernyak
- Publisher
- Impact Journals, LLC
- Published
- 2015
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)