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IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C by Thomas J. Urban; Alexander J. Thompson; Shelton S. Bradrick; Jacques Fellay; Detlef Schuppan; Kenneth D. Cronin; Linda Hong; Alexander McKenzie; Keyur Patel; Kevin V. Shianna; John G. McHutchison; David B. Goldstein; Nezam Afdhal is a Medicine article available to read on EtoBox.
What is IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C about?
Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon-a and ribavirin. We hypothesized that IL28B polymorphism is associated with intrahepatic expression of interferon-stimulated genes (ISGs), known to influence treatment outcome. IL28B genotyping (rs12979860) and whole-genome RNA expression were performed using liver biopsies from 61 North American patients with CHC. After correction for multiple testing (false discovery rate < 0.10), 164 transcripts were found to be differentially expressed by IL28B-type. The interferon signaling pathway was the most enriched canonical pathway differentially expressed by IL28B-type (P < 10 25 ), with most genes showing higher expression in livers of individuals carrying the poor-response IL28B-type. In 25 patients for which treatment response data were available, IL28B-type was associated with SVR (P 5 0.0054). ISG expression was also associated with SVR; however, this was not independent of IL28B-type. Analysis of miR-122 expression in liver biopsies showed reduced miR-122 level
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- Author
- Thomas J. Urban; Alexander J. Thompson; Shelton S. Bradrick; Jacques Fellay; Detlef Schuppan; Kenneth D. Cronin; Linda Hong; Alexander McKenzie; Keyur Patel; Kevin V. Shianna; John G. McHutchison; David B. Goldstein; Nezam Afdhal
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)