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The Japanese cord blood bank network experience with cord blood transplantation from unrelated donors for haematological malignancies: an evaluation of graft‐versus‐host disease prophylaxis by Hirokazu Nishihira; Koji Kato; Keiichi Isoyama; Tsuneo A. Takahashi; Shunro Kai; Shunichi Kato; Minoko Takanashi; Norihiro Sato; Hiroyuki Sato; Kohichi Kitajima; Tomoki Naoe; Hidehiko Saito is a Medicine article available to read on EtoBox.

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**Summary.** Cryopreserved umbilical cord blood (CB) from unrelated donors can restore haematopoiesis after myeloablative therapy in patients with haematological malignancy. We investigated the clinical outcomes of CB transplantation (CBT) with special emphasis on graft‐versus‐host disease (GVHD) prophylaxis. Patients with haematological malignancies (__n__ = 216) received intensive chemotherapy or immunosuppressive therapy, followed by transplantation of cryopreserved CB cells from unrelated donors. The clinical outcomes, i.e. haematological reconstitution, the incidence of acute or chronic GVHD, relapse and event‐free survival (EFS), were evaluated. The estimated probability of neutrophil recovery was 88·2%. The median follow‐up for the survivors was 557 d (range 21–1492 d). The overall and EFS rates were 32·6% and 25·5%, respectively, 3·5 years after transplantation. Multivariate analysis using Cox's proportional hazards model showed that high‐risk disease status at CBT and single‐drug GVHD prophylaxis were associated with worse 2‐year EFS rates [__P =__ 0·0013, relative risk (RR) 1·90, 95% confidence interval (CI) 1·28–2·81 and __P__ = 0·0007, RR 1·91, 95% CI 1·31–2·79 respecti

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Author

Hirokazu Nishihira; Koji Kato; Keiichi Isoyama; Tsuneo A. Takahashi; Shunro Kai; Shunichi Kato; Minoko Takanashi; Norihiro Sato; Hiroyuki Sato; Kohichi Kitajima; Tomoki Naoe; Hidehiko Saito

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2003

Language

EN

Field

Medicine (Health Sciences)